Gamuts

Coffin-Siris syndrome

Coffin–Siris Syndrome is a rare genetic disorder that causes developmental delays and absent fifth finger and toe nails. There had been 31 reported cases by 1991. [Source: Wikipedia ]

Synonyms
Dwarfism-onychodysplasia
Fifth digit syndrome
Short stature - onychodysplasia.
OrphaNet reference
Coffin-Siris syndrome 
May Cause
Absent clavicle
Alopecia
Clavicle hypoplasia
Clinodactyly of fifth finger
Cone-shaped epiphysis
Congenital elbow anomaly
Congenital intestinal malrotation
Congenital joint subluxation
Coxa valga
Delayed bone age
Dense epiphyses of hands and feet
Elbow dislocation
Eyelid ptosis
Hirsutism
Hypoplastic terminal phalanges
Intestinal malrotation
Irregular epiphysis
Joint laxity
Joint subluxation
Low hairline
Macular stains
Microcephaly
Nail aplasia
Nail deformity
Nail dystrophy
Nail hypoplasia
Periauricular pits
Periauricular tag
Retarded skeletal maturation
Sclerotic epiphysis
Short metacarpal
Short metatarsal
Thin and small distal phalanges of the hand
Thin clavicle

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