OrphaNet reference

Sclerosteosis 

May Cause

Calvarial hyperostosis

Cataract

Congenital macrocephaly

Congenital prognathism

Congenital widespread osteosclerosis

Cranial nerve paresis or paralysis

Craniotubular dysplasia

Deafness

Defective dentition

Delayed dentition

Dense or thick skull

Dental defect

Diffusely dense skull base

Exophthalmos

Frontal bossing

Gigantism

Hyperphosphatasemia

Hypertelorism

Macrocephaly

Nail aplasia

Nail deformity

Nail dystrophy

Nail hypoplasia

Optic atrophy

Osteosclerosis

Sclerosing bone dysplasia

Short middle phalanges

Syndactyly

Thick clavicle

Thick ribs

Thick tubular hand bones

Transverse dense metaphyseal bands

Widespread osteosclerosis of medullary and cortical bone

Widespread predominantly medullary osteosclerosis

Wormian bones