Gamuts

Craniodiaphyseal dysplasia

Craniodiaphyseal dysplasia (CDD), also known as lionitis, is an extremely rare autosomal recessive bone disorder that causes calcium to build up in the skull, disfiguring the facial features and reducing life expectancy. These calcium deposits decrease the size of cranial foramina, and can decrease the circumference of the cervical spinal canal. [Source: Wikipedia ]

OrphaNet reference
Craniodiaphyseal dysplasia 
May Cause
Absent paranasal sinus
Broad tubular bones
Calvarial hyperostosis
Choanal atresia
Choanal stenosis
Clavicular lesion in an infant or child
Congenital hydrocephalus
Congenital macrocephaly
Congenital prognathism
Congenital widespread osteosclerosis
Cranial nerve paresis or paralysis
Craniotubular dysplasia
Dense or thick skull
Diffusely dense skull base
Erlenmeyer flask deformity
Frontal bossing
Hydrocephalus
Hypoplastic paranasal sinus
Macrocephaly
Multiple opaque jaw lesions
Multiple sclerotic foci in an infant or child
Osteosclerosis
Sclerosing bone dysplasia
Small foramen magnum
Symmetrical anterior rib flaring
Thick clavicle
Thick ribs
Thick skull
Thick tubular hand bones
Underdeveloped mastoid
Underdevelopment of mastoids
Wide diametaphysis
Wide metaphysis
Widespread cortical bone thickening
Widespread predominantly cortical osteosclerosis

Copyright © 2022, Charles E. Kahn, Jr., MD, MS
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