May Cause

Acquired absence of phalanx, digit, hand, or foot

Acro-osteolysis

Avascular necrosis

Brachydactyly

Corneal abnormality

Defective dentition

Degenerative joint changes

Delayed dentition

Early loss of teeth

Excess callus formation

Hip dislocation

Hip subluxation

Hypoplastic terminal phalanges

Limb reduction

Localized wide epiphyseal plate

Metaphyseal cupping

Multiple fractures

Neuropathic arthropathy

Neuropathic bone changes of the hands or feet

Neuropathy

Pathologic fracture

Premature tooth loss

Self-mutilation

Solitary collapsed vertebra

Tongue abnormality

Tongue ulcer

Widespread periosteal reaction