Optic nerve coloboma-renal disease

Paired box gene 2, also known as PAX2 is a protein which in humans is encoded by the PAX2 gene. Function The Pax Genes, or Paired-Box Containing Genes, play important roles in the development and proliferation of multiple cell lines, development of organs, and development and organization of the central nervous system. [Source: Wikipedia ]

May Cause
Coloboma