Clouston syndrome

Clouston's hidrotic ectodermal dysplasia is caused by mutations in a connexin gene, GJB6 or connexin-30, characterized by scalp hair that is wiry, brittle, and pale, often associated with patchy alopecia. Presentation Hidrotic ectodermal dysplasia 2, or Clouston syndrome (referred to as HED2 throughout this entry) is characterized by partial or total alopecia, dystrophy of the nails, hyperpigmentation of the skin (especially over the joints), and clubbing of the fingers. [Source: Wikipedia ]

Synonyms
Alopecia congenita with keratosis palmoplantaris
Clouston hidrotic ectodermal dysplasia
Fischer-Jacobsen-Clouston syndrome
Hidrotic ectodermal dysplasia
May Cause
Alopecia
Cataract
Ectodermal dysplasia
Ichthyosis
Nail aplasia
Nail deformity
Nail dystrophy
Nail hypoplasia
Onycholysis
Skin pigment abnormality
Strabismus
Thick skull