Depressed nasal bridge

Pentasomy X, also known as 49,XXXXX, is a chromosomal abnormality in which a female has five X chromosomes instead of the normal two. Signs may include intellectual disability, short height, low-set ears, decreased muscle tone, and developmental delay. [Source: Wikipedia ]

Flat nasal bridge
May Be Caused by
Achondrogenesis type 2
Aminopterin fetopathy
Anderson syndrome
Antley-Bixler syndrome
Apert syndrome
Binder syndrome
Brachmann-de Lange syndrome
Campomelic dysplasia
Cardio-facio-cutaneous syndrome
Carpenter syndrome
Cenani-Lenz syndactyly syndrome
Cephaloskeletal dysplasia
Chondrodysplasia punctata
Chromosome 6p deletion
Chudley-Lowry syndrome
Cleidocranial dysostosis
Cloverleaf skull deformity
Costello syndrome
Craniofacial-deafness-hand syndrome
Craniometaphyseal dysplasia
Ectodermal dysplasia
EEC syndrome
Ehlers-Danlos syndrome
Fetal hydantoin syndrome
Fetal trimethadione syndrome
Fetal valproate syndrome
Fraser syndrome
Frontonasal dysplasia
Gardner-Silengo-Wachtel syndrome
GM1 gangliosidosis
Hennekam syndrome
Hereditary agenesis of nasal cartilage
Holt-Oram-like syndrome
Hurler syndrome
Immuno-osseous dysplasia Schimke type
Kenny-Caffey dysplasia type 1
Keutel syndrome
Kniest syndrome
Laron syndrome
Larsen syndrome
Lethal micromelic-facial bones sclerosis dysplasia
Lethal osteosclerotic skeletal dysplasia
Marshall syndrome
Marshall-Smith syndrome
Mietens-Weber syndrome
MMMM syndrome
Mucolipidosis type 2
Mucopolysaccharidosis type 1-S
Mucopolysaccharidosis type 6
Nasodigitoacoustic syndrome
Neu-Laxova syndrome
Noonan syndrome
Opitz trigonocephaly syndrome
Orofaciodigital syndrome
Osteogenesis imperfecta type 1
Osteogenesis imperfecta type 2
Otopalatodigital syndrome type 2
Pallister-Killian syndrome
Pfeiffer syndrome
Pierpont syndrome
Proteus syndrome
Relapsing polychondritis
Ritscher-Shinzel syndrome
Robinow syndrome
Rothmund-Thomson syndrome
Saethre-Chotzen syndrome
Schinzel-Giedion syndrome
Short rib-polydactyly syndrome
Skeletal dysplasia-Opalescent/Rootless Teeth ***
Smith-Magenis syndrome
Stickler syndrome
Teebi hypertelorism syndrome
Thanatophoric dysplasia
Trisomy 21
Warfarin embryopathy
Weill-Marchesani syndrome
Williams syndrome
XXXXX syndrome
XXXXY syndrome