Melnick-Needles osteodysplasty

Melnick–Needles syndrome (MNS), also known as Melnick–Needles osteodysplasty, is an extremely rare congenital disorder that affects primarily bone development. Patients with Melnick–Needles syndrome have typical faces (exophthalmos, full cheeks, micrognathia and malalignment of teeth), flaring of the metaphyses of long bones, s-like curvature of bones of legs, irregular constrictions in the ribs, and sclerosis of base of skull.In males, the disorder is nearly always lethal in infancy. [Source: Wikipedia ]

Melnick-Needles dysplasia
Melnick-Needles syndrome
Osteodysplasty Melnick-Needles type
OrphaNet reference
Osteodysplasty, Melnick-Needles type 
May Cause
Absent clavicle
Absent digit
Absent paranasal sinus
Anterior vertebral scalloping
Bowed bones
Bowed tubular bones
Cervical kyphosis
Clavicle dysplasia
Clavicle hypoplasia
Clavicular lesion in an infant or child
Congenital coxa vara
Congenital vertebral abnormality
Congenital widespread osteosclerosis
Congenitally abnormal pelvis
Coxa valga
Craniotubular dysplasia
Defective dentition
Defective pubic ossification
Delayed bone age
Delayed closure of fontanelles
Delayed dentition
Dense or thick skull
Dental defect
Diffusely dense skull base
Erlenmeyer flask deformity
External ear malformation
Genu valgum
Hooked clavicle
Hypoplastic paranasal sinus
Hypoplastic pelvis
Inner ear anomaly
Joint subluxation
Large fontanelle
Lethal skeletal dysplasia
Metaphyseal cupping
Middle ear anomaly
Nail aplasia
Nail deformity
Nail dystrophy
Nail hypoplasia
Narrow pelvis in an infant or child
Pectus excavatum
Pulmonary hypertension
Retarded skeletal maturation
Rib anomaly
Rib notching
Ribbon-like ribs
Short broad distal phalanx of thumb
Short narrow thoracic cage
Short ribs
Small acetabular angle
Small sella turcica
Soft-tissue calcification
Spool-shaped vertebrae
Tall vertebrae
Thick clavicle
Thin and small distal phalanges of the hand
Thin clavicle
Thin ribs
Thoracic dysplasia
Twisted bones
Type B pelvis
Wavy ribs
Wide metaphysis
Wide pubic symphysis
Widespread osteosclerosis
May Be Caused by
Gurrieri syndrome
Melnick-Needles dysplasia
Melnick-Needles syndrome
Osteodysplasty Melnick-Needles type