Solitary well-demarcated lytic bone lesion

Common: Amyloidosis; Bone cyst; Bone infarct; Brodie abscess; Brown tumor of hyperparathyroidism; Cortical/periosteal desmoid; Cystic osteomyelitis; Enchondroma; Fibrous cortical defect; Fibrous dysplasia; Giant cell tumor; Gouty tophus; Intraosseous ganglion; Langerhans cell histiocytosis; Metastasis; Nonossifying fibroma; Renal cell carcinoma metastasis; Subchondral cyst; Thyroid carcinoma metastasis; Villonodular synovitis
Uncommon: Adamantinoma; Ameloblastoma; Aneurysmal bone cyst; Benign tropical ulcer; Blastomycosis; Bone hemangioma; Chondroblastoma; Chondromyxoid fibroma; Chondrosarcoma; Coccidioidomycosis; Cystic type lymphangioma; Desmoplastic fibroma; Epidermoid inclusion cyst; Fibrosarcoma; Foreign body; Fungal granuloma; Glomus tumor; Hemophilic pseudotumor; Histoplasmosis duboisii; Hydatid cyst; Lipoma; Liposclerosing myxofibrous tumor; Malignant fibrous histiocytoma; Multiple myeloma; Myxofibroma; Myxoma; Neurofibroma; Osteoblastoma; Osteofibrous dysplasia; Osteoid osteoma; Paget disease of bone; Periosteal chondroma; Periosteal fibroma; Plasmacytoma; Sarcoidosis; Telangiectatic osteosarcoma; Tuberculosis; Tuberculous granuloma