Coloboma

A coloboma (from the Greek koloboma, meaning defect) is a hole in one of the structures of the eye, such as the iris, retina, choroid, or optic disc. The hole is present from birth (except for one case, where it developed within the first few months of the child's life) and can be caused when a gap called the choroid fissure, which is present during early stages of prenatal development, fails to close up completely before a child is born. [Source: Wikipedia ]

May Be Caused by
Acrorenalocular syndrome
Agenesis of the corpus callosum - intellectual deficit - coloboma - micrognathia
Aicardi syndrome
Alar cartilages hypoplasia - coloboma - telecanthus
Aniridia-Wilms tumor association
Baraitser-Winter syndrome
Biemond syndrome type 2
Brachmann-de Lange syndrome
Branchiooculofacial syndrome
Burn-McKeown syndrome
Cat-eye syndrome
CHARGE syndrome
CHARGE-like syndrome
CHIME syndrome
Chondrodysplasia punctata and ocular colobomata
Chondrodysplasia-pseudohermaphrodism
Chromosome 9p-like syndrome
Chromosome syndrome
COACH syndrome
Cohen syndrome
Coloboma-radial aplasia syndrome
Contractural arachnodactyly
Crouzon syndrome
Delleman syndrome
Dobrow syndrome
Donnai-Barrow syndrome
Epidermal nevus syndrome
Facio-oculo-acoustico-renal syndrome
Familial imperforate anus-cleft lip-coloboma
Fetal alcohol syndrome
Fetal hydantoin syndrome
Frontofacionasal dysplasia
Frontonasal dysplasia
Gillespie syndrome
Goldberg-Shprintzen syndrome
Goltz syndrome
Gorlin syndrome
Hirschsprung-coloboma syndrome
Holoprosencephaly
Hydrolethalus
Hypospadias - hypertelorism - coloboma and deafness
Joubert syndrome
Kabuki syndrome
LEOPARD syndrome
Marfan syndrome
Meckel syndrome
MICRO syndrome
Microcornea - posterior megalolenticonus - persistent fetal vasculature - coloboma
Microcornea syndrome
MOMO syndrome
Morning glory syndrome
Moyamoya
Nager acrofacial dysostosis
Nasopalpebral lipoma-coloboma syndrome
Noonan syndrome
Oculo-auriculo-vertebral spectrum
Oculo-oto-dental syndrome
Optic nerve coloboma-renal disease
Orofaciodigital syndrome
Pallister-Hall syndrome
Parietal bone agenesis-plus
PHACE association
Phillips-Griffiths syndrome
Renal-coloboma syndrome
Renal-coloboma-arthrogryposis syndrome
Rieger syndrome
Ritscher-Shinzel syndrome
Rubinstein-Taybi syndrome
Scapuloiliac dysostosis
Sorsby syndrome
Steinfeld syndrome
Sturge-Weber syndrome
Temtamy syndrome
Terminal osseous dysplasia-pigmentary defect
Townes-Brocks syndrome
Treacher Collins syndrome
Trichorhinophalangeal dysplasia type 2
White sponge nevus-ocular coloboma