CADASIL

CADASIL or CADASIL syndrome, involving cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy, is the most common form of hereditary stroke disorder, and is thought to be caused by mutations of the Notch 3 gene on chromosome 19. The disease belongs to a family of disorders called the leukodystrophies. [Source: Wikipedia ]

Synonyms
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy
Hereditary multi-infarct dementia
OrphaNet reference
CADASIL 
May Cause
Alopecia
Arterial occlusion
Atherosclerosis
Encephalopathy