An osteosarcoma (OS) or osteogenic sarcoma (OGS) (or simply bone cancer) is a cancerous tumor in a bone. Specifically, it is an aggressive malignant neoplasm that arises from primitive transformed cells of mesenchymal origin (and thus a sarcoma) and that exhibits osteoblastic differentiation and produces malignant osteoid.Osteosarcoma is the most common histological form of primary bone sarcoma. [Source: Wikipedia ]

OrphaNet reference
Is A
Bone sarcoma
Extraskeletal osteosarcoma
Fibroblastic osteosarcoma
Giant cell-rich osteosarcoma
Gnathic osteosarcoma
High-grade intramedullary osteosarcoma
High-grade surface osteosarcoma
Intracortical osteosarcoma
Low-grade intramedullary osteosarcoma
Mesenchymal osteosarcoma
Parosteal osteosarcoma
Periosteal osteosarcoma
Small-cell osteosarcoma
Telangiectatic osteosarcoma
May Cause
Abnormal contour of calvarium
Bone tumor with periosteal reaction
Calcification in lymph nodes
Calcified liver metastasis
Calcified pulmonary metastasis
Chest wall lesion
Chest wall neoplasm
Clavicular lesion in an infant or child
Cystic liver metastasis
Dense temporal bone lesion
Densely sclerotic vertebra
Dental periapical opacity
Diametaphyseal bone lesion
Diaphyseal bone lesion
Enlargement or erosion of sella turcica
Fingertip calcification
Floating teeth
Focal calcification in kidney
Focal vertebral sclerosis
Focally dense calvarium
Focally dense skull base
Hair-on-end skull
Hyperdense intracranial lesion
Hyperechoic liver metastasis with acoustic shadowing
Infratemporal fossa lesion
Juxtadiaphragmatic lesions in children
Large destructive bone lesion
Large pelvic soft-tissue mass
Lesion of hard palate
Lesion of soft palate
Localized bulge of the calvarium or scalp
Localized periosteal reaction
Localized sunburst pattern in skull
Long rib lesion
Lower abdominal calcification
Lytic jaw lesion with internal residual bone
Malformed orbit
Malignant primary bone neoplasm
Masticator space lesion
Metaphyseal bone lesion
Mixed-radiopacity jaw lesion
Nasopharyngeal lesion
Nonvisceral abdominal calcification
Orbital wall sclerosis
Osseous paranasal sinus lesion
Osteoblastic metastases
Osteolytic lesion with calcium attenuation
Paranasal sinus mass
Pediatric chest tumor
Pediatric chest wall lesion
Periosteal new bone formation in a child
Periosteal reaction involving the clavicle
Permeative osteolytic lesion
Pleural calcification
Posterior mediastinal lesion
Posterior skull base lesion
Radiolucent skull lesion
Renal mass with calcification
Renal parenchymal tumor
Rib lesion in a child
Sacral neoplasm
Sacrococcygeal lesion
Sclerosis of bone with periosteal reaction
Sclerosis of the orbital roof
Sclerotic clavicle
Sclerotic foot bone lesion
Sclerotic hand bone lesion
Short rib lesion
Sinus disease with bone destruction
Small optic canal
Small orbit
Soft-tissue mass with adjacent bone erosion
Soft-tissue tumor with associated calcification
Solid renal mass
Solitary bone lesion with expansile remodeling
Solitary collapsed vertebra
Solitary ill-defined lytic metaphyseal lesion
Solitary large calcified soft tissue mass adjacent to bone
Solitary lytic diaphyseal bone lesion
Solitary opacity in jaw
Solitary osteosclerotic bone lesion
Solitary permeative metaphyseal lesion
Solitary poorly demarcated osteolytic bone lesion
Spiculated periosteal reaction
T1-hypointense intracranial lesion
T1-isointense intracranial lesion
T2-hypointense intracranial lesion
T2-hypointense musculoskeletal lesion
T2-isointense intracranial lesion
Temporal bone neoplasm
Thick clavicle
Unilateral exophthalmos
Urothelial tumor
Vertebral neoplasm
Vertebral pedicle sclerosis
Well-defined expansile radiolucent jaw lesion
Widespread areas of bone destruction
May Be Caused by
Avascular necrosis
Bone infarct
Chronic osteomyelitis
Fibrous dysplasia
Healed fracture
Metallic implant
OSLAM syndrome
Osteogenesis imperfecta
Paget disease of bone
Radiation therapy
Rothmund-Thomson syndrome